Impedance or dielectric spectroscopy is the ultra-low energy technique to study charge distributions, polarization, and electrical dynamics in matter. The PDP will develop ultra-sensitive and ultra-low frequency dielectric spectrometers to detect and study the secondary structure and intramolecular structural motifs of peptides and proteins. This will also include the study of intra- and interchain interactions and dynamics within a protein. Once the instrumentation is developed, the study will generate a reproducible array or catalog of dielectric responses of intramolecular structural motifs, thus providing scientists a tool to study proteins in their natural aqueous environment and promoting the fundamental fields of biophysics, biochemistry, and proteomics.
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